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Like teeth, it is recommended that you brush your dentures after every meal. Obviously, this is not always a practical option. But you should clean your dentures as soon after you eat as possible. Take the dentures out and hold with your thumb and forefinger. Make sure wherever you are cleaning them, it is never over a hard surface. Put a towel down on the vanity, or make sure the sink is full of water. If you drop them, they will not break. Get a good denture brush and denture cleaner, both available in every day drugstores and brush thoroughly, as you would if the teeth were in your mouth. Avoid using bleaching agents, as they will discolor the pink acrylic for the gum line.
This is a must ! Check with your denturist. If your dentures are not in your mouth, there is usually extra care you should be taking with them - and you want to make sure you fully understand what that care is. You've spent too much on your dentures to not double check with your denturist.